Regularized finite mixture models for probability trajectories

Finite mixture models are widely used in the analysis of growth trajectory data to discover subgroups of individuals exhibiting similar patterns of behavior over time. In practice, trajectories are usually modeled as polynomials, which may fail to capture important features of the longitudinal pattern. Focusing on dichotomous response measures, we propose a likelihood penalization approach for parameter estimation that is able to capture a variety of nonlinear class mean trajectory shapes with higher precision than maximum likelihood estimates. We show how parameter estimation and inference for whether trajectories are time-invariant, linear time-varying, or nonlinear time-varying can be carried out for such models. To illustrate the method, we use simulation studies and data from a long-term longitudinal study of children at high risk for substance abuse.