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Related Experiment Video

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Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
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BDNF genotype modulates resting functional connectivity in children.

Moriah E Thomason1, Daniel J Yoo, Gary H Glover

  • 1Department of Psychology, Stanford University Stanford, CA 94305-2130, USA. moriah@stanford.edu

Frontiers in Human Neuroscience
|December 4, 2009
PubMed
Summary
This summary is machine-generated.

The brain-derived neurotrophic factor (BDNF) gene affects brain network connectivity in children. Methionine allele carriers show altered connectivity in memory and emotion circuits, potentially explaining neuropsychiatric differences.

Keywords:
BDNFadolescentschildrenfMRIfunctional connectivitygeneresting-state

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Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Psychology

Background:

  • Brain-derived neurotrophic factor (BDNF) gene variants are linked to brain structure and memory. Altered hippocampal function is observed in adults with the BDNF methionine (met) allele. BDNF plays a role in neurogenesis and synapse formation.
  • The impact of BDNF gene variants on functional brain network connectivity, particularly in children and adolescents, remains largely uncharacterized.

Purpose of the Study:

  • To investigate the association between BDNF gene variants and resting-state functional connectivity in the brains of children and adolescents.
  • To explore potential neural mechanisms linking BDNF gene variants to neuropsychiatric disorders through altered brain network connectivity.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) was used to assess neural connectivity.
  • Participants were children and adolescents genotyped for BDNF gene variants, specifically the methionine (met) allele.

Main Results:

  • Met-allele carriers exhibited reduced hippocampal and parahippocampal to cortical connectivity within default-mode and executive networks.
  • Increased connectivity to amygdala, insula, and striatal regions was observed in met-allele carriers within the paralimbic network.
  • Spatial topography of resting-state networks in youth mirrored adult patterns.

Conclusions:

  • The BDNF gene influences functional connectivity at the neural systems level in children and adolescents.
  • Altered connectivity in emotion-processing circuits in met-allele carriers may represent a neural mechanism underlying BDNF gene-related neuropsychiatric differences.
  • Resting-state network organization is conserved across development from childhood to adulthood.