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Updated: Jun 18, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
[Study on the relationship between hepatocellular carcinoma and the interaction between polymorphisms in DNA repair
Xiao-Yun Zeng1, Xiao-Qiang Qiu, Long Ji
1Public Health School, Guangxi Medical University, Nanning, China.
Objective:
To study the relationship between hepatocellular carcinoma and the interaction of polymorphisms in DNA repair gene XPD with environmental factors.
Methods:
A hospital-based case-control study on hepatocellular carcinoma was conducted. All the hepatocellular carcinoma cases (n=300) were newly diagnosed and controls (n=312) were diagnosed with non-tumor cases. XPD genotype (Lys751 Gln and Asp312 Asn) from blood derived DNA was determined using TaqMan MGB Real-time PCR. Unconditional logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs).
Results:
For XPD condon 751 genotypes, there was no significant difference between frequencies of the AC or CC among patients and controls (P>0.05) (referent AA). The frequency of XPD312A allelic gene was higher in cases than that in controls and was associated with an increased risk (adjusted OR=2.62, 95% CI: 1.626-4.222) for hepatocellular carcinoma when compared with GG genotype. Interactions were found between infection of HBsAg and XPD312 (OR=7.348), as well as between smoking and non-wild type gene of XPD751 (OR=4.291) and XPD312 (OR=5.341).
Conclusion:
DNA repair XPD312A allelic gene might increase the risk of Hepatocellular carcinoma. Interactions between HBsAg infection, smoking and XPD were observed in Hepatocellular carcinoma.
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