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Related Experiment Video

Updated: Jun 18, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

Aspirin resistance.

Khaled Mansour¹, Ali T Taher, Khaled M Musallam

¹Division of Cardiology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.

Advances in Hematology

|December 5, 2009

Summary

Aspirin resistance, or treatment failure, is a growing concern for cardiovascular event prevention. Understanding its causes and improving management strategies are crucial for patient outcomes.

Area of Science:

Cardiology
Pharmacology
Clinical Medicine

Background:

Adverse cardiovascular events occur despite aspirin therapy, indicating potential aspirin resistance.
Multiple definitions and laboratory tests for aspirin resistance exist, leading to varied prevalence data.
Etiologic factors include clinical, genetic, and miscellaneous influences.

Purpose of the Study:

To explore the phenomenon of aspirin resistance in cardiovascular disease.
To review the definitions, diagnostic methods, and prevalence of aspirin resistance.
To discuss the implications and current management strategies for aspirin resistance.

Main Methods:

Literature review of studies on aspirin resistance.
Analysis of definitions and laboratory testing modalities.

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Synthesis of information on etiologic factors and clinical implications.

Main Results:

Aspirin resistance is reported with a wide prevalence across different clinical settings.
Clinical, genetic, and other factors contribute to aspirin resistance.
Current management strategies like dose adjustment or adding other antiplatelet agents show limited efficacy and safety.

Conclusions:

Aspirin resistance poses significant clinical challenges.
Existing management strategies for aspirin resistance are insufficient.
Further research is needed to develop effective and safe treatments for aspirin resistance.