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Standard Solutions01:14

Standard Solutions

Standard solutions refer to solutions with a precisely known concentration or composition. A primary standard is a highly pure, high molar mass, stable substance that is entirely soluble in water, the most commonly used solvent in analytical chemistry. The primary standard solution can be used to standardize secondary standards, which are substances with known concentrations but are less pure and stable. Standard solutions are essential for achieving accurate and reliable results in analytical...
Units and Standards of Measurement01:10

Units and Standards of Measurement

A physical quantity is defined either by specifying its measurement method or by stating how it is calculated from other measurements. For example, consider a metallic cube. We might define its mass and dimensions by specifying methods for measuring them, such as using a weighing machine and a meter scale. Then, we could define the volume by stating that it is the cube of its side, and we could calculate the density as the mass divided by the volume.
Measurements of physical quantities are...
Units and Standards of Measurement01:10

Units and Standards of Measurement

A physical quantity is defined either by specifying its measurement method or by stating how it is calculated from other measurements. For example, consider a metallic cube. We might define its mass and dimensions by specifying methods for measuring them, such as using a weighing machine and a meter scale. Then, we could define the volume by stating that it is the cube of its side, and we could calculate the density as the mass divided by the volume.
Measurements of physical quantities are...
Conversion of Units01:36

Conversion of Units

Sometimes, there is a need to convert from one unit to another one. For instance, reading a cookbook in which quantities are expressed in units of liters or ounces may require conversion of quantities to cups. Or, when looking up directions on how to get to a location, we may be interested to know how many miles we are going to walk. In this case, we would have to convert units of feet or meters to miles.
The first step in the unit conversion is to list the given units and the units required...
Harmonic Mean01:09

Harmonic Mean

The arithmetic mean is usually skewed towards the larger values in the data set. Therefore, to avoid this inherent bias towards smaller values, the harmonic mean is used.
Take the example of the speed of a car, which is the measure of the rate of distance traveled. If the vehicle traverses the same distance back-and-forth, its average speed equals the total distance traveled divided by the total time taken. However, if the car moves with varying speeds, then the arithmetic mean is more skewed...
Instrument Calibration01:12

Instrument Calibration

Instrument calibration is essential for ensuring that instruments produce accurate and consistent results. It is vital in manufacturing, healthcare, testing laboratories, and scientific research. Calibration processes are specific to each instrument and help enhance data accuracy. Each instrument has a unique calibration process tailored to its design and function to improve data accuracy.
Analytical Balance Calibration
An analytical balance measures mass and requires regular calibration to...

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Related Experiment Video

Updated: Jun 18, 2026

Reproducibility and Harmonization in Research Using Biological Standards: The Example of Platelet Agonist Collagen-Related Peptide
04:50

Reproducibility and Harmonization in Research Using Biological Standards: The Example of Platelet Agonist Collagen-Related Peptide

Published on: August 4, 2023

Standardization, Harmonization, and Realization.

Nicole L Gentile1, Richard F Louie, Jorge Sifontes

  • 1Point-of-Care Technologies Center (National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health), Point-of-Care Testing Center for Teaching and Research, Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, CA.

Point of Care
|December 5, 2009
PubMed
Summary
This summary is machine-generated.

Point-of-care testing (POCT) quality can be improved through whole-blood standards, method harmonization, and tighter quality control. These enhancements will lead to better diagnoses, treatment decisions, and patient outcomes in critical care settings.

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Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children
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Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children

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Related Experiment Videos

Last Updated: Jun 18, 2026

Reproducibility and Harmonization in Research Using Biological Standards: The Example of Platelet Agonist Collagen-Related Peptide
04:50

Reproducibility and Harmonization in Research Using Biological Standards: The Example of Platelet Agonist Collagen-Related Peptide

Published on: August 4, 2023

Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children
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Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children

Published on: February 10, 2023

Area of Science:

  • Clinical Chemistry
  • Point-of-Care Diagnostics
  • Medical Laboratory Science

Background:

  • Point-of-care testing (POCT) is vital in hospitals and emergency situations.
  • Current POCT practices lack standardization, harmonization, and consistency.
  • These deficiencies limit the potential of POCT to improve patient care.

Purpose of the Study:

  • To propose key improvements for professional practice in point-of-care testing.
  • To enhance the quality and reliability of diagnostic results obtained at the point of care.
  • To ultimately improve patient diagnoses, treatment decisions, and health outcomes.

Main Methods:

  • Advocating for the adoption of whole-blood standards in POCT.
  • Recommending harmonization initiatives among various POCT methods.
  • Proposing the implementation of stricter quality control constraints for POCT.

Main Results:

  • Implementing whole-blood standards will enhance consistency across different testing platforms.
  • Harmonizing testing methods will reduce variability and improve comparability of results.
  • Tighter quality control will ensure greater accuracy and reliability of POCT results.

Conclusions:

  • The proposed "three wishes"—whole-blood standards, method harmonization, and tighter quality control—are essential for advancing POCT.
  • These improvements will significantly enhance the quality of care delivered at the point of care.
  • Successful implementation will lead to more accurate diagnoses, optimized treatment strategies, and improved patient outcomes.