[Radiation modifying effect of hyperglycemia: correlation between glucose dose and tumor size]

Experiments were made on rats with transplantable sarcoma-45 and sarcoma M-1. Dose correlation was established during a study of hyperglycemic radiomodifying action. Glucose injection at a dose of 6-17.5 g/kg was shown to enhance irradiation action. Glucose injection below or above these doses might cause worse radiotherapy results or even the death of animals. The best effect was obtained with small-size tumors. Large tumors (over 2 cm3) were less sensitive to hyperglycemia combined with irradiation. Skin radioprotective action of hyperglycemia before irradiation increased with an increase in a dose. The authors proposed a method of radioprotective action of hyperglycemia on normal tissues, enhancing simultaneously the antitumor effect of irradiation.