[Effects of short-term hyperglycemia on the state of brain function in patients with neurological neoplasms]

The paper is concerned with the results of investigation of the effect of short-term hyperglycemia on main cerebral functions in neuro-oncological patients. Clinical and paraclinical control in the course of investigation revealed insignificant and transient changes of the neurological status, ECG and investigated cerebral functions. In a lesser group of patients changes over time were unobserved. Taking into account good tolerance of short-term hyperglycemia and the results of its effective use in general oncology, one can recommend it as a modifier in radiation therapy of brain gliomas. Proceeding from the obtained experimental data on a similar tumor model as well as positive results of the use of short-term hyperglycemia in general oncology, its use appeared to be most effective after tumor irradiation. Taking into account a certain degree of unreliability of the method (catheterization of the subclavicular vein), requiring strict control on the part of medical personnel, the use of short-term hyperglycemia could be effectively implemented during large-fractionated irradiation of brain gliomas.