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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.

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Related Experiment Video

Updated: Jun 18, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

[Cutaneous lymphomas].

Saskia Ingen-Housz-Oro1, Martine Bagot

  • 1Service de dermatologie, CHU Henri-Mondor, AP-HP, 94000 Créteil, France. saskia.oro@hmn.aphp.fr

La Revue Du Praticien
|December 8, 2009
PubMed
Summary

Cutaneous lymphomas, affecting the skin, are classified into B-cell and T-cell types. Prognosis varies by subtype and requires staging for treatment decisions.

Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Background:

  • Cutaneous lymphomas are skin-exclusive lymphoproliferations.
  • They are broadly categorized into B-cell and T-cell types.
  • Prognosis is determined by histological subtype and staging.

Purpose of the Study:

  • To classify cutaneous lymphomas based on cell type and behavior.
  • To outline diagnostic staging procedures.
  • To inform therapeutic decision-making.

Main Methods:

  • Histological subtyping of B-cell and T-cell lymphomas.
  • Staging evaluation including CT scans, bone marrow examination, and lymph node biopsy.
  • Clinical assessment of prognosis based on subtype and stage.

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Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors
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Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Published on: January 7, 2019

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Last Updated: Jun 18, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors
08:39

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Published on: January 7, 2019

Main Results:

  • Cutaneous B-cell lymphomas include indolent (marginal zone, follicle center) and aggressive (diffuse large B-cell lymphoma, leg type) subtypes.
  • Cutaneous T-cell lymphomas include indolent (mycosis fungoides, lymphomatoid papulosis) and aggressive (Sezary syndrome, CD30- lymphomas) subtypes.
  • Staging is crucial for determining appropriate treatment.

Conclusions:

  • Accurate classification and staging of cutaneous lymphomas are essential for patient prognosis and treatment.
  • Understanding the distinct characteristics of B-cell and T-cell cutaneous lymphomas guides clinical management.
  • Comprehensive staging ensures tailored therapeutic strategies for improved outcomes.