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A pilot study of fat allograft transplantation in immunocompetent rabbits for potential neurosurgical applications
John S Kuo1, Cynthia Hawkins, James T Rutka
1Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, University of Toronto, Ontario, Canada. j.kuo@neurosurg.wisc.edu
Object:
The authors investigated the feasibility of using fat allografts (chemically treated to reduce the host immune response) for neurosurgical applications.
Methods:
Subcutaneous fat specimens collected from New Zealand White rabbits were treated with DNAse I and sodium deoxycholate to reduce immunogenicity before subcutaneous, midscapular implantation in immunocompetent recipient rabbits. Allograft incorporation and the host-allograft response were examined at 1, 6, and 11 weeks by histopathological analysis. Control specimens of autograft and untreated fat allograft implants were examined for comparison.
Results:
The host immune response was markedly reduced in the region around the chemically treated fat allografts when compared with untreated allografts, and was similar to the tolerant host response to autografts.
Conclusions:
Based on their results, the authors suggest that fat allografts processed for reduced immunogenicity may be a convenient, viable alternative for neurosurgical applications.
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