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Updated: Jun 18, 2026
Preparation of Frozen Non-Human Primate Fetal Islets for Combined Single Nuclei RNA-Sequencing and ATAC-Sequencing, and Bulk Metabolomics
Published on: November 8, 2024
A crucial step in assisted reproduction technology: human embryo selection using metabolomic evaluation
Frutos Carlos Marhuenda-Egea1, Encarnación Martínez-Sabater, Rubén Gonsálvez-Alvarez
1Department of Agrochemistry and Biochemistry, University of Alicante, Alicante, Spain. frutos@ua.es
Abstract:
We present a new methodology to predict embryo viability in assisted reproductive technology (ART) treatments by determining the relative amino acid concentrations in human embryo culture medium on day 3, using high-performance liquid chromatography with mass spectroscopy analysis without derivatization. The model was performed with soft independent modeling of class analogy for the samples from nonpregnancy and pregnancy cases.
