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Updated: Jun 18, 2026
11:02
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[Bladder replacement and cancer of the bladder]
1Service d'urologie, hôpital Foch, Suresnes, France. t.lebret@hopital-foch.org, lebret@worldnet.fr
Summary
Radical cystectomy with neo-bladder reconstruction offers a 90% 5-year survival for localized bladder cancer. Orthotopic neobladder using ileum provides effective urinary diversion and continence recovery.
Area of Science:
- Urology
- Surgical Oncology
Context:
- Bladder cancer treatment
- Muscle-invasive and resistant superficial urothelial tumors
Purpose:
- Evaluate radical cystectomy and neobladder reconstruction outcomes
- Discuss urinary diversion techniques
Summary:
- Radical cystectomy is indicated for muscle-infiltrating or treatment-resistant superficial bladder tumors.
- Orthotopic neobladder using a short ileal segment (under 50 cm) is preferred for urinary diversion, preserving the urethra.
- Successful neobladder creation requires adherence to surgical principles, with improved pre- and post-operative care facilitating recovery and continence.
Impact:
- Achieves 90% 5-year specific survival for localized bladder tumors (
- Orthotopic neobladder facilitates functional recovery and continence.
- Regular follow-up is crucial for detecting relapses and ensuring proper neobladder function.
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