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Updated: Jun 18, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
Analysis of urinary function using validated instruments and uroflowmetry after primary and salvage prostate
Masaki Kimura1, Vladimir Mouraviev, Matvey Tsivian
1Division of Urologic Surgery, Department of Surgery, Duke Prostate Center, Duke University Medical Center, Durham, North Carolina 27710, USA.
Cryoablation for prostate cancer generally maintains urinary function, with most patients showing improvement within 18 months. Salvage cryoablation may slightly impact urinary function, but overall, it
Area of Science:
- Urology
- Oncology
- Minimally Invasive Surgery
Background:
- Cryoablation is a treatment option for localized prostate cancer.
- Understanding its impact on urinary function is crucial for patient management.
Purpose of the Study:
- To evaluate urinary function changes post-cryoablation for prostate cancer.
- To identify predictors of urinary function changes after the procedure.
Main Methods:
- Retrospective analysis of 74 patients undergoing cryoablation (primary or salvage).
- Assessment of preoperative and postoperative urinary function using International Prostate Symptom Score (IPSS), bother index, and uroflowmetry.
- Analysis of factors including surgical approach, preoperative symptoms, and prostate volume.
Main Results:
- Only 2.7% experienced mild stress incontinence; no persistent retention or fistula reported.
- International Prostate Symptom Score (IPSS) and bother index scores improved by 12 and 18 months, respectively.
- Salvage cryoablation was associated with urinary function decline (P=.032), while patients with severe preoperative symptoms or larger prostates showed improvement.
Conclusions:
- Cryoablation is a minimally invasive procedure for localized prostate cancer.
- The study demonstrates cryoablation's capacity to maintain or improve urinary function.
- Validated instruments and uroflowmetry confirm positive functional outcomes post-cryoablation.
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