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Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway
Chris R Evelyn1, Jessica L Bell, Jenny G Ryu
1Department of Pharmacology, University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109, USA.
Abstract:
We recently identified bis(amide) CCG-1423 (1) as a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis. An initial structure-activity relationship study focusing on bioisosteric replacement of the amides and conformational restriction identified two compounds, 4g and 8, with improved selectivity for inhibition of RhoA/C-mediated gene transcription and attenuated cytotoxicity relative to 1. Both compounds were also capable of inhibiting cell invasion with equal efficacy to 1 but with less attendant cytotoxicity.
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