Satellite nanoscope and cellular BioASICs for quantitative biomedicine

This paper presents satellite nanoscopes and biological application specific integrated circuits (BioASICs). Satellite nanoscope is developed for spectroscopic imaging of living cells, molecular optogenetics (i.e. the remote control of gene regulation and protein expression), and therapeutic applications. Fundamental understanding of living cells via satellite nanoscopes will provide insights of molecular dynamics and signaling pathways in living cells. BioASICs are accomplished to permit precise and repeatable characterizations of cellular activity. These BioASICs are facilitating significant advancements in quantitative cell biology and the foundation for precision biology, cell reprogramming, highspeed biologic microprocessors, drug screening, molecular diagnostics, and personalized medicine.