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Updated: Jun 18, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
A personalized and optimal approach for dosing contrast material at coronary computed tomography angiography
John F Kalafut1, Corey A Kemper, Pal Suryani
1MEDRAD Inc, Indianola, PA 15051, USA. jkalafut@medrad.com
Abstract:
A method for constructing a personalized contrast medium protocol at contrast enhanced, Coronary CT Angiography (CCTA) is presented. A one compartment pharmacokinetic model is parameterized and identified with a minimal data set from a test-bolus injection. A direct-search optimization is performed to construct a protocol that achieves target enhancement in the cardiac structures. Clinical results demonstrating the method's ability to achieve prospectively chosen image enhancement levels while reducing contrast medium dose are presented.
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Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...