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Reticular Dermis

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...

Elastin is Responsible for Tissue Elasticity

Elastin is Responsible for Tissue Elasticity

Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
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Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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[Mid-dermal elastolysis].

D Helbig¹, M Schlaak, R Renner

¹Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Abt. Dermatohistologie, Universität Leipzig, Philipp Rosenthal Str. 23, 04103, Leipzig. doris.helbig@medizin.uni-leipzig.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|December 8, 2009

Summary

This summary is machine-generated.

Mid-dermal elastolysis, a rare skin condition, involves elastic tissue loss. This case highlights extensive wrinkling after UV exposure, prompting further investigation into its causes and variants.

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Published on: October 25, 2018

Area of Science:

Dermatology
Histopathology

Background:

Mid-dermal elastolysis is a rare skin disease characterized by the loss of elastic tissue in the mid-dermis.
Its etiology remains unknown, with described variants including papular, plaque-like, inflammatory, and non-inflammatory forms.

Observation:

A 39-year-old patient presented with significant skin wrinkling on the trunk and upper extremities.
This condition developed subsequent to extensive exposure to ultraviolet (UV) light.

Findings:

Clinical and histopathological findings of the patient were documented.
Histopathology confirmed the characteristic mid-dermal loss of elastic tissue.

Implications:

The case contributes to understanding mid-dermal elastolysis, particularly its potential link to UV exposure.
Differential diagnoses are discussed, and existing literature is reviewed to provide a comprehensive overview.