Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inborn errors of immunity in Low German Mennonite communities in Mexico: a case series and narrative literature review.

Frontiers in immunology·2026
Same author

Design of a multi-epitope Staphylococcus aureus vaccine integrating a protein A variant, α-hemolysin, and fibronectin-binding protein A through reverse vaccinology.

Scientific reports·2026
Same author

Description of invasive aspergillosis in Mexican patients with chronic granulomatous disease.

Journal of human immunity·2026
Same author

Clinical features, genotypes, and geographic distribution of 238 Latin American CGD patients.

Journal of human immunity·2026
Same author

Immune Privilege of the Eye: A Delicate Balance Between Clarity and Chaos.

Ocular immunology and inflammation·2026
Same author

Clinical and Genetic Characteristics of Patients With Novel and Uncertain Significance Variants in CTLA4: A Mexican Cohort.

Clinical genetics·2026

Related Experiment Video

Updated: Jun 17, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

[Chronic granulomatous disease].

Aristóteles Alvarez-Cardona1, Marco Antonio Yamazaki-Nakashimada, Sara Elva Espinosa-Padilla

  • 1Instituto Nacional de Pediatria, Cuicuilco, México, DF. dr.aristoteles@yahoo.com.mx

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|December 17, 2009
PubMed
Summary

Chronic granulomatous disease (CGD) is an inherited immune disorder affecting phagocytes. Early diagnosis and treatment significantly improve outcomes for patients with this rare condition.

Area of Science:

  • Immunology
  • Genetics

Context:

  • Chronic granulomatous disease (CGD) is a primary immunodeficiency affecting phagocytes, occurring in approximately 1 in 200,000 live births.
  • It results from mutations in genes encoding the nicotinamide adenine dinucleotide phosphate oxidase (NADPH) enzyme, crucial for reactive oxygen species (ROS) production.

Purpose:

  • To outline the genetic basis, clinical manifestations, diagnosis, and treatment of Chronic Granulomatous Disease.
  • To highlight the importance of early diagnosis and current therapeutic strategies in managing CGD.

Summary:

  • CGD is caused by genetic mutations impairing NADPH oxidase function, preventing ROS production and leading to neutrophil dysfunction.
  • Patients experience recurrent, severe infections (e.g., Staphylococcus, fungi) and inflammatory conditions like granulomas and abscesses.

Related Experiment Videos

Last Updated: Jun 17, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

  • Diagnosis involves clinical suspicion, family history, and confirmation via ROS production tests and genetic mutation analysis.

    • Impact:

    • Allogeneic stem cell transplantation offers a curative option for CGD.
    • Prophylactic antibiotics and interferon-gamma therapy have significantly improved the morbidity and mortality rates associated with CGD.