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Related Experiment Video

Updated: Jun 17, 2026

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

Elevated high sensitivity C-reactive protein levels in aging men with low testosterone.

Steven A Kaplan1, Amy O Johnson-Levonas, Jianxin Lin

  • 1Cornell University, New York, NY 10021, USA. kaplans@med.cornell.edu <kaplans@med.cornell.edu>

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
|December 17, 2009
PubMed
Summary

Low testosterone levels are linked to higher cardiovascular inflammation in aging men. This suggests low T may increase heart disease risk, impacting sexual function and overall health.

Related Experiment Videos

Last Updated: Jun 17, 2026

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Men's Health

Background:

  • Testosterone (T) plays a role in men's health.
  • High-sensitivity C-reactive protein (hsCRP) is a marker of cardiovascular inflammation.
  • The relationship between T and hsCRP in aging men requires further investigation.

Purpose of the Study:

  • To assess the relationship between serum testosterone levels and hsCRP in aging men.
  • To determine if lower testosterone is associated with increased cardiovascular inflammation.

Main Methods:

  • Analysis of baseline data from 467 men (mean age 52 years) in a lipid treatment study.
  • Categorization of men into four testosterone subgroups: <6.9 nmol/l, 6.9 to <10.4 nmol/l, 10.4 to <15 nmol/l, and >= 15 nmol/l.
  • Examination of hsCRP levels across these testosterone subgroups, considering lipid and anthropometric data.

Main Results:

  • A significant difference in median hsCRP levels was observed across testosterone subgroups (p=0.041).
  • Men with lower testosterone levels exhibited higher median hsCRP levels.
  • The prevalence of elevated hsCRP (>2 mg/l) was significantly higher in men with low testosterone (83% for T < 6.9 nmol/l) compared to those with normal testosterone (40% for T >= 15 nmol/l).

Conclusions:

  • An inverse relationship exists between serum testosterone and hsCRP in aging men.
  • Low testosterone may contribute to increased cardiovascular risk in hypogonadal men.
  • Urologists should consider the cardiovascular implications of low testosterone in aging men, beyond sexual dysfunction.