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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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Clinical trials for progressive differentiated thyroid cancer: patient selection, study design, and recent advances

Martin Schlumberger1, Steven I Sherman

  • 1Department of Nuclear Medicine and Endocrine Oncology, Referral Center for Refractory Thyroid Tumors, Institut National du Cancer, Institut Gustave Roussy , Villejuif, France. schlumbg@igr.fr

Thyroid : Official Journal of the American Thyroid Association
|December 17, 2009
PubMed

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...