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Related Concept Videos

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Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
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Related Experiment Video

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Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
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Relationship between hemoglobin and CD40 ligand in prediabetes.

Mustafa Kutlu1, Alper Sonmez, Halil Genc

  • 1Department of Endocrinology, Gulhane Medical School, Etlik, 06018 Ankara, Turkey.

Clinical and Investigative Medicine. Medecine Clinique Et Experimentale
|December 17, 2009
PubMed
Summary

Higher hemoglobin (Hb) levels in individuals with impaired glucose tolerance (IGT) are linked to increased cardiovascular risk factors, including higher blood pressure and specific inflammatory markers. Further research is needed to clarify the clinical implications for prediabetes.

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Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Hemoglobin (Hb) plays a role in endothelial function by influencing nitric oxide bioavailability.
  • Prediabetes, characterized by impaired glucose tolerance (IGT), is associated with elevated risks of cardiovascular disease and mortality.
  • Understanding the relationship between Hb levels and cardiovascular risk factors in IGT is crucial for early intervention.

Purpose of the Study:

  • To investigate the association between hemoglobin (Hb) levels and classical cardiac risk factors in subjects with impaired glucose tolerance (IGT).
  • To examine the relationship of Hb levels with markers of endothelial dysfunction and inflammation in individuals with IGT.

Main Methods:

  • Sixty-nine normotensive, cardiovascular event-free subjects with IGT were enrolled.
  • Measurements included plasma insulin, high-sensitivity C-reactive protein (hsCRP), soluble CD40L, von Willebrand factor, and p-selectin.
  • Participants were stratified based on median Hb values for comparative analysis.

Main Results:

  • Higher Hb levels correlated with lower HDL-C, elevated systolic and diastolic blood pressure, and increased soluble CD40L.
  • Hb levels showed significant correlations with HDL cholesterol, sCD40L, blood pressure, and waist circumference.
  • Multiple logistic regression identified Hb as a determinant of soluble CD40L levels.

Conclusions:

  • Higher hemoglobin values in individuals with IGT may be associated with increased cardiovascular risk factors.
  • These findings suggest a potential link between Hb levels and cardiovascular risk in the prediabetes stage.
  • Further research is warranted to elucidate the clinical significance of these associations in prediabetes.