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Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
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Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...
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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Oral contraceptives: does formulation matter?

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Preventing injuries and illnesses in the wilderness.

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Comparison of misoprostol plasma concentrations following buccal and sublingual administration.

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Low-dose mifepristone for contraception: a weekly versus planned postcoital randomized pilot study.

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Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery
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Mifepristone: ten years later.

Eric A Schaff1

  • 1Department of Pediatrics, Temple University School of Medicine, Philadelphia, PA 19140, USA. eric.schaff@tuhs.temple.edu

Contraception
|December 17, 2009
PubMed
Summary

Mifepristone offers a safe medical abortion option, overcoming historical challenges. Research continues to improve access and address barriers, enhancing its effectiveness and safety for women globally.

Area of Science:

  • Reproductive Health
  • Pharmacology
  • Medical Science

Background:

  • Historically, safe and effective abortifacients were unavailable, posing risks to pregnant women.
  • Mifepristone, an anti-progesterone and anti-glucocorticoid medication, revolutionized medical abortion.
  • Despite its benefits, mifepristone use is associated with political controversies and access barriers.

Purpose of the Study:

  • To review the historical context and discovery of mifepristone for medical abortion.
  • To identify and analyze the barriers limiting mifepristone's effectiveness and accessibility.
  • To highlight ongoing research efforts to improve mifepristone-based abortion.

Main Methods:

  • Literature review of historical and contemporary research on mifepristone.

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  • Analysis of studies addressing challenges in medical abortion.
  • Examination of factors influencing clinical provision of mifepristone.

    • Main Results:

    • Mifepristone has been used by millions worldwide for medical abortion.
    • Key barriers include gestational age limits, process complexity, cost, and side effects.
    • Researchers are actively working to overcome these limitations.

    Conclusions:

    • Mifepristone represents a significant advancement in reproductive healthcare.
    • Continued research is crucial for improving medical abortion protocols and accessibility.
    • Addressing barriers will expand safe abortion options for women.