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Related Experiment Video

Updated: Jun 17, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

[Sorafenib-induced multiple eruptive keratoacanthomas].

H Jantzem1, D Dupre-Goetghebeur, P Spindler

  • 1Centre régional de pharmacovigilance de Brest, CHU La-Cavale-Blanche, boulevard Tanguy-Prigent, 29609 Brest cedex, France. helene.jantzem@chu-brest.fr

Annales De Dermatologie Et De Venereologie
|December 17, 2009
PubMed
Summary
This summary is machine-generated.

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Sorafenib, used for kidney cancer, can cause a rare skin reaction called eruptive keratoacanthomas. These lesions resolved after stopping the drug, suggesting a potential immunosuppressive effect.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Sorafenib is approved for metastatic renal cell carcinoma.
  • Common side effects include rash and hand-foot syndrome.
  • An unexpected cutaneous effect, multiple keratoacanthomas, is presented.

Observation:

  • A 64-year-old man developed dome-shaped nodules with central keratotic cores.
  • Histology confirmed eruptive keratoacanthomas after three weeks of sorafenib treatment.
  • Lesions regressed three weeks after discontinuing sorafenib.

Findings:

  • The case suggests sorafenib may have an immunosuppressant mechanism.
  • Drug-induced keratoacanthomas are rare but linked to immunosuppression.
  • Sorafenib's complex activity may include effects beyond tyrosine kinase inhibition.

Related Experiment Videos

Last Updated: Jun 17, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Implications:

  • This finding broadens the understanding of sorafenib's side effect profile.
  • Highlights the importance of monitoring for rare dermatological reactions.
  • Suggests potential for immunosuppression-related adverse events with novel antineoplastics.