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Updated: Jun 17, 2026

Animal Models of Depression - Chronic Despair Model (CDM)
Published on: September 23, 2021
An evaluation of an integrated model of relapse in depression
Barbara J Backs-Dermott1, Keith S Dobson, Shannon L Jones
1Alberta Health Services - Calgary Region, Canada. barb.backsdermott@albertahealthservices.ca
Background And Aim:
The present study evaluated an integrated model of the role of psychosocial factors in the prediction of relapse of Major Depressive Disorder over a one-year follow-up period.
Methods And Analyses:
A range of established variables, including life stress, cognitive-personality vulnerability factors, social support, and coping responses, were simultaneously considered in a series of prediction models, in an adult female sample of remitted depressed individuals.
Results:
It was determined that interpersonal marked difficulties, social support, and emotion-oriented and avoidance-oriented coping provided the best-fitting and most parsimonious predictive model for depressive relapse at one-year follow-up.
Conclusions:
The examination of multifactorial models of risk represents a promising avenue for future research and theory development.
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