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Correlation of CSF proinflammatory cytokines with MRI in tuberculous meningitis

Abhishek Yadav1, Chaynika Chaudhary, Anuradha H Keshavan

  • 1Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh 226014, India.

Academic Radiology
|December 17, 2009
PubMed
Abstract

Insights

Diffusion tensor imaging (DTI) shows correlation between cerebrospinal fluid (CSF) proinflammatory cytokines and imaging parameters in tuberculous meningitis (TBM). DTI may help assess treatment response in TBM patients.

Area of Science:

  • Neuroimaging
  • Infectious Diseases
  • Biomarkers

Background:

  • Tuberculous meningitis (TBM) is a severe infection affecting the central nervous system.
  • Cerebrospinal fluid (CSF) biomarkers, including proinflammatory cytokines (PCs), are elevated in TBM.
  • Conventional MRI may not fully capture the extent of meningeal inflammation in TBM.

Purpose of the Study:

  • To correlate CSF proinflammatory cytokines (PCs) with diffusion tensor imaging (DTI) parameters in TBM patients.
  • To assess changes in DTI parameters after antitubercular treatment (ATT).

Main Methods:

  • Forty TBM patients and 30 controls underwent MRI with DTI at baseline and 6 months after ATT.
  • CSF PCs were quantified at baseline.
  • Fractional anisotropy (FA) and post-contrast signal intensity (PCSI) were analyzed.

Main Results:

  • Significant positive correlation between PCs and FA/PCSI in cerebral cortical regions of TBM patients.
  • Higher FA values in TBM patients compared to controls at baseline.
  • Decreased FA and PCSI after 6 months of ATT.

Conclusions:

  • DTI-derived anisotropy can delineate meningeal inflammation in TBM.
  • DTI may serve as an additional tool for assessing therapeutic response in TBM.

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