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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

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Neurologic varicella complications before routine immunization in Germany.

Anita L Rack¹, Veit Grote, Andrea Streng

¹Dr. von Haunersches Kinderspital, University Children's Hospital Munich, Munich, Germany.

Pediatric Neurology

|December 17, 2009

Summary

This summary is machine-generated.

Neurologic complications frequently hospitalized children with varicella, most commonly acute cerebellar ataxia and febrile convulsions. These complications impacted immunocompetent children more often than immunocompromised ones.

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Area of Science:

Pediatrics
Infectious Diseases
Neurology

Background:

Varicella (chickenpox) is a common, highly infectious childhood illness.
Neurologic complications can arise from varicella infection.
Understanding the incidence and types of these complications is crucial for pediatric care.

Purpose of the Study:

To determine the incidence and types of neurologic complications in children hospitalized with varicella.
To identify risk factors and outcomes associated with these complications.

Main Methods:

Prospective nationwide surveillance of hospitalized varicella cases in Germany (2003-2004).
Data collected through the German Pediatric Surveillance Unit for Rare Diseases.
Analysis of demographic, clinical, and outcome data for children up to 16 years old.

Main Results:

Neurologic complications occurred in 25.4% of hospitalized children, being the most frequent reason for admission.
Acute cerebellar ataxia (31.0%) and febrile convulsions (29.7%) were the most common diagnoses.
Complications were more frequent in immunocompetent (32%) versus immunocompromised (4%) children.
Sequelae were observed in 12% of affected children, with 3 deaths.

Conclusions:

Neurologic complications are a significant cause of hospitalization for children with varicella.
Cerebellar ataxia and convulsions are the primary neurologic manifestations.
Immunocompetent children are at higher risk for these complications.