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Fluorinated piperidine acetic acids as gamma-secretase modulators

Matthew G Stanton1, Jed Hubbs, David Sloman

  • 1Department of Drug Design and Optimization, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA. matthew_stanton@merck.com

Bioorganic & Medicinal Chemistry Letters
|December 17, 2009
PubMed
Summary

Researchers developed new difluoropiperidine acetic acids to modulate gamma-secretase. These compounds selectively reduced amyloid-beta 42 (Abeta42) in mice without causing Notch-related side effects in rats.

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