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Updated: Jun 17, 2026
09:44
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
[Acute on chronic liver failure]
Angels Escorsell Mañosa1, Antoni Mas Ordeig
1UCI-Institut de Malalties Digestives i Metabòliques, Hospital Clínic, IDIBAPS, Universitat de Barcelona, CIBERehd, Barcelona, España. aescor@clinic.ub.es
Gastroenterologia Y Hepatologia
|December 17, 2009
Summary
Acute-on-Chronic Liver Failure (ACLF) involves severe liver deterioration, often leading to organ failure and high mortality. Liver transplantation is preferred but limited, necessitating alternative treatments for ACLF patients.
Area of Science:
- Hepatology
- Critical Care Medicine
- Transplantation
Background:
- Acute-on-Chronic Liver Failure (ACLF) is a severe clinical syndrome.
- It is characterized by acute deterioration of pre-existing liver disease, often cirrhosis.
- ACLF presents with hepatorenal syndrome, hepatic encephalopathy, and multi-organ failure.
Purpose of the Study:
- To define Acute-on-Chronic Liver Failure (ACLF).
- To highlight the clinical manifestations and high short-term mortality risk.
- To discuss treatment options, including liver transplantation.
Main Methods:
- The abstract does not specify methods.
- It is a descriptive overview of ACLF.
Main Results:
- ACLF has a high incidence (40% at 5 years) in advanced cirrhosis patients.
- This translates to approximately 4,000 European cases annually.
- High short-term mortality is a key feature.
Conclusions:
- Liver transplantation is the primary treatment for ACLF.
- Organ shortage and patient morbidity/mortality necessitate exploring alternative therapies.
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