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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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Related Experiment Video

Updated: Jun 17, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Switching on epigenetic therapy.

Sascha Karberg

    Cell
    |December 17, 2009
    PubMed
    Summary

    Reversible epigenetic changes, known as epimutations, are hallmarks of various diseases. Biotechnology firms are developing novel therapeutics to correct these pathogenic alterations in gene expression.

    Area of Science:

    • Molecular Biology
    • Genetics
    • Epigenetics

    Background:

    • Epigenetic modifications, such as DNA methylation and histone alterations, play crucial roles in regulating gene expression.
    • Aberrant epigenetic changes, termed epimutations, are increasingly recognized as significant contributors to the development and progression of various diseases, including cancer.
    • These epimutations are potentially reversible, offering therapeutic opportunities.

    Purpose of the Study:

    • To highlight the role of reversible epigenetic changes in disease pathogenesis.
    • To underscore the emerging therapeutic strategies targeting epimutations.

    Main Methods:

    • Review of current scientific literature on epigenetics and disease.
    • Analysis of trends in biotechnology drug development focused on epigenetic targets.

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    In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
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    In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

    Published on: May 5, 2023

    Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins
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    Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins

    Published on: October 31, 2025

    Related Experiment Videos

    Last Updated: Jun 17, 2026

    Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
    10:28

    Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

    Published on: September 20, 2018

    In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
    10:44

    In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

    Published on: May 5, 2023

    Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins
    09:56

    Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins

    Published on: October 31, 2025

    Main Results:

    • Epigenetic dysregulation is a common feature across a spectrum of human diseases.
    • Biotechnology companies are actively investing in and developing drugs designed to reverse pathogenic epimutations.
    • These novel drugs aim to restore normal gene expression patterns by targeting epigenetic mechanisms.

    Conclusions:

    • Reversible epigenetic modifications represent a critical area of research and therapeutic development.
    • Targeting epimutations holds promise for treating a range of diseases characterized by altered gene expression.