Related Experiment Videos
Serum calcium and breast cancer risk in a prospective cohort study
Brian L Sprague1, Halcyon G Skinner, Amy Trentham-Dietz
1Department of Population Health Sciences and Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53726, USA. bsprague@wisc.edu
Abstract:
Calcium has anti-proliferative and pro-differentiation effects on mammary cells in vitro and can inhibit the development of mammary tumors in mice. While there is some epidemiologic evidence for an inverse relation between dietary calcium intake and breast cancer risk, only one previous study has examined serum calcium levels in relation to breast cancer risk. We investigated this relation in a prospective cohort study of 2,762 women, aged 43-86, who were enrolled in the Beaver Dam Eye Study in 1988 and followed for up to 19 years. We found no evidence for an association between breast cancer risk and either total (hazard ratio, HR = 0.98; 95% CI: 0.60-1.60; 4(th) vs. 1(st) quartile) or ionized (HR = 0.85; 95% CI: 0.53, 1.38; 4(th) vs. 1(st) quartile) serum calcium levels. Additionally, we found no evidence for an association among subgroups defined by menopausal status and body mass index.
Related Concept Videos
Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Skeleton and Calcium Homeostasis
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Synthesis and Functions of Calcitonin
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
Cancer Prevention
Some...
Cancer Prevention
Some...