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Phosphorylated hamartin-Hsp70 complex regulates apoptosis via mitochondrial localization.

Hirofumi Inoue1, Takumi Uyama, Tsukasa Suzuki

  • 1Department of Applied Biology and Chemistry, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.

Biochemical and Biophysical Research Communications
|December 17, 2009
PubMed
Summary

Hamartin, a Tuberous Sclerosis Complex (TSC) protein, inhibits apoptosis by localizing to mitochondria. This process requires hamartin phosphorylation and binding to Heat Shock Protein 70 (Hsp70).

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