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Related Experiment Video

Updated: Jun 17, 2026

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm

Published on: June 7, 2018

Olfactory priming reinstates extinguished chocolate-induced conditioned place preference.

Immacolata La Mela¹, Emanuele Claudio Latagliata, Enrico Patrono

¹Santa Lucia Foundation, European Centre for Brain Research (CERC), Rome, Italy.

|December 17, 2009

Summary

Olfactory priming can reinstate extinguished food cravings in mice, suggesting smell plays a key role in relapse for eating disorders. This finding offers new avenues for treating conditions like obesity.

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Area of Science:

Neuroscience
Behavioral Science
Physiology

Background:

Relapse into maladaptive eating habits is a significant challenge in managing excessive eating disorders like obesity.
Olfaction plays a crucial role in regulating appetite and eating behaviors.

Purpose of the Study:

To investigate the potential of olfactory priming to reinstate extinguished conditioned place preference for palatable food in a mouse model.
To explore the role of smell in relapse behavior associated with eating disorders.

Main Methods:

Utilized a conditioned place preference model in sated mice.
Extinguished the chocolate-induced conditioned place preference.
Administered olfactory priming to assess reinstatement of the preference.

Main Results:

Olfactory priming successfully reinstated extinguished chocolate-induced conditioned place preference in the experimental group.
Olfactory priming was ineffective in inducing conditioned place preference in the control group.
These findings demonstrate the efficacy of olfactory priming in an animal model of relapse.

Conclusions:

Olfactory cues can trigger relapse in eating behaviors, even after extinction.
Smell is a critical factor to consider in developing effective treatments for eating disorders and preventing relapse.
This study provides novel insights into the neurobiological mechanisms underlying food seeking and relapse.