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Sesquiterpene lactones from Sonchus arvensis L. and their antibacterial activity against Streptococcus mutans ATCC
Zhengxiang Xia1, Wei Qu, Haiying Lu
1Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, PR China. xzx5380537@163.com
Abstract:
Two new sesquiterpene lactones, 1beta-sulfate-5alpha, 6betaH-eudesma-3-en-12, 6alpha-olide (1) and 1beta-(p-hydroxyphenyl acetyl)-15-O-beta-D-glucopyranosyl-5alpha, 6betaH-eudesma-3-en-12, 6alpha-olide (2) were isolated from Sonchus arvensis L. (Asteraceae), together with eight known compounds. Their structures were elucidated through spectroscopic and chemical methods. They were evaluated for antibacterial activity. Among them, compounds 1 and 7 exhibited antibacterial activity against oral pathogen Streptococcus mutans ATCC 25175 with MIC values of 15.6 and 62.5 microg/ml, respectively.
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