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Dishevelled: The hub of Wnt signaling

Chan Gao1, Ye-Guang Chen

  • 1Tsinghua University, Beijing, China. ygchen@tsinghua.edu.cn

Cellular Signalling
|December 17, 2009
PubMed

Insights

Dishevelled (Dvl) protein is crucial for Wnt signaling, regulating development and cell polarity. This review details Dvl

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cell Signaling

Background:

  • Wnt signaling pathways are essential for diverse biological processes, including embryonic development and tissue homeostasis.
  • Dishevelled (Dvl) is a pivotal protein that acts as a signal transducer in various Wnt pathways.
  • Dysregulation of Wnt signaling is implicated in numerous diseases.

Purpose of the Study:

  • To provide a comprehensive review of Dishevelled (Dvl) protein functions in Wnt signal transduction.
  • To elucidate the roles of Dvl in mammalian development and its associated molecular mechanisms.
  • To summarize the dynamic regulation of Dvl activity through post-translational modifications.

Main Methods:

  • Literature review of existing research on Dishevelled (Dvl) protein.
  • Analysis of studies investigating Wnt signaling pathways, including canonical and non-canonical routes.
  • Examination of data on Dvl's interactions with other proteins and its role in cellular processes.

Main Results:

  • Dishevelled (Dvl) protein mediates Wnt signals through interactions with Frizzled receptors and downstream effectors.
  • Dvl plays critical roles in both canonical (beta-catenin dependent) and non-canonical Wnt pathways (e.g., PCP, Daam1-RhoA, Rac1).
  • Dvl is involved in diverse cellular functions, including receptor endocytosis and modulation of microtubule dynamics, and its activity is regulated by phosphorylation and ubiquitination.

Conclusions:

  • Dishevelled (Dvl) is a multifunctional protein essential for Wnt signal transduction and embryonic development.
  • Understanding Dvl's complex regulatory mechanisms and diverse functions is key to comprehending Wnt pathway biology.
  • Further research into Dvl's roles may offer insights into therapeutic strategies for developmental disorders and cancer.

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