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Updated: Jun 17, 2026

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
Subacute fulminant hepatic failure with intermittent fever
Cong-Xin Chen1, Bo Liu, Yong Hu
1Department of Infectious Diseases, 105th Hospital, Hefei 230031, China. congxinc@mail.hf.ah.cn
Background:
Viral hepatitis B accounts for over 80% of acute hepatic failures in China and the patients die mainly of its complications. A patient with hepatic failure and fever is not uncommon, whereas repeated fever is rare.
Methods:
A 32-year-old female was diagnosed with subacute hepatic failure and hepatitis B viral infection because of hyperbilirubinemia, coagulopathy, hepatic encephalopathy, serum anti-HBs-positive without hepatitis B vaccination, and typical intrahepatic pathological features of chronic hepatitis B. Plasma exchange was administered twice and she awoke with hyperbilirubinemia and discontinuous fever.
Results:
Urethritis was confirmed and medication-induced fever and/or spontaneous bacterial peritonitis (Gram-negative bacillus infection) was suspected. The patient was treated with antibiotics, steroids and a Chinese herbal medicine, matrine, for three months and she recovered.
Conclusion:
The survival rate of patients with hepatic failure might be improved with comprehensive supporting measures and appropriate, timely management of complications.
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