Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a Large Animal Rectovaginal Fistula Model.

Urogynecology (Philadelphia, Pa.)·2026
Same author

Age disparity in robotic colorectal surgery: overcoming surgeon hesitancy to improve elderly patient outcomes.

Journal of robotic surgery·2026
Same author

Local Recurrence Rates in Locally Advanced Rectal Cancer Are Higher with KRAS Codon 13 Mutations.

Journal of gastrointestinal cancer·2025
Same author

Conventional Versus High-Complexity Total Pelvic Exenteration for Locally Advanced and Locally Recurrent Rectal Cancer: An International Multicenter Study.

Diseases of the colon and rectum·2025
Same author

Downstaged lateral pelvic lymph nodes require no resection after neoadjuvant therapy and total mesorectal excision.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2025
Same author

Magnetic Resonance Imaging for Distinguishing Perianal Hidradenitis Suppurativa from Fistulizing Crohn Disease.

Dermatology (Basel, Switzerland)·2025

Related Experiment Video

Updated: Jun 17, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
08:20

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

Proctocolectomy and brooke ileostomy for chronic ulcerative colitis.

Eric J Dozois1

  • 1Division of Colon and Rectal Surgery, Mayo Clinic Foundation, Rochester, MN 55905, USA. dozois.eric@mayo.edu

Clinics in Colon and Rectal Surgery
|December 17, 2009
PubMed
Summary

Proctocolectomy with permanent ileostomy offers a surgical option for ulcerative colitis patients, particularly the elderly or those with rectal cancer. This one-stage procedure is simpler and has fewer complications than ileal pouch-anal anastomosis.

Keywords:
Brooke ileostomyUlcerative colitisproctocolectomy

More Related Videos

Murine Ileocolic Bowel Resection with Primary Anastomosis
08:49

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

Related Experiment Videos

Last Updated: Jun 17, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
08:20

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

Murine Ileocolic Bowel Resection with Primary Anastomosis
08:49

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

Area of Science:

  • Gastroenterology and Colorectal Surgery

Background:

  • Ulcerative colitis (UC) management often requires surgical intervention for refractory disease.
  • Proctocolectomy with permanent ileostomy is a viable surgical option for specific UC patient groups.

Purpose of the Study:

  • To outline the indications and advantages of proctocolectomy with permanent ileostomy for ulcerative colitis.
  • To discuss the surgical technique for this procedure.

Main Methods:

  • Review of current indications for proctocolectomy and permanent ileostomy.
  • Description of the operative technique.

Main Results:

  • Proctocolectomy and permanent ileostomy is indicated for elderly patients, those with poor anal continence, and rectal malignancy.
  • Advantages include fewer complications compared to ileal pouch-anal anastomosis, a single-stage removal of diseased tissue, and relative surgical simplicity.

Conclusions:

  • Proctocolectomy with permanent ileostomy is a safe and effective surgical option for selected ulcerative colitis patients.
  • The procedure offers distinct benefits over alternative surgical approaches in specific patient populations.