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Updated: Jun 17, 2026

In vitro Functional Characterization of Mouse Colorectal Afferent Endings
Published on: January 21, 2015
Functional anorectal disorders
Melissa L Times1, Craig A Reickert
1Division of Colon & Rectal Surgery, Henry Ford Hospital, Detroit, MI 48202, USA.
Functional anorectal disorders present with constipation and other symptoms. Diagnosis requires a combination of clinical evaluation and specialized tests, with medical treatments like biofeedback being the first line.
Area of Science:
- Gastroenterology and Colorectal Surgery
- Pelvic Floor Disorders
Background:
- Functional anorectal disorders encompass conditions such as solitary rectal ulcer syndrome, rectocele, nonrelaxing puborectalis syndrome, and descending perineal syndrome.
- Patients often report "constipation" but exhibit a complex clinical picture including rectal pain, bleeding, digital manipulation, incomplete evacuation, and obstruction sensation.
Purpose of the Study:
- To outline the diagnostic challenges and current management strategies for functional anorectal disorders.
- To emphasize the multidisciplinary approach required for accurate diagnosis and effective treatment.
Main Methods:
- Diagnosis relies on integrating clinical presentation with objective assessments.
- Key diagnostic tools include defecography, anorectal manometry, pudendal terminal motor nerve latency studies, and histopathological examination.
- Clinical assessment is crucial, as many findings overlap with normal physiological variations.
Main Results:
- Accurate diagnosis is often challenging due to the non-specific nature of symptoms and overlapping findings.
- A combination of clinical evaluation and specialized investigations is necessary for definitive diagnosis.
- Medical management, including dietary modifications and biofeedback therapy, is the primary treatment approach.
Conclusions:
- Functional anorectal disorders require a comprehensive diagnostic workup.
- Non-surgical interventions are the mainstay of treatment.
- Surgical options are limited to refractory cases and have variable outcomes.
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