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Related Concept Videos

Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: Jun 17, 2026

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
08:55

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Published on: May 18, 2018

Ischemic colitis.

Mark Y Sun1, Justin A Maykel

  • 1Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Clinics in Colon and Rectal Surgery
|December 17, 2009
PubMed
Summary
This summary is machine-generated.

Ischemic colitis, a common gastrointestinal ischemia, presents with abdominal pain and bloody diarrhea. Treatment varies from supportive care for mild cases to surgery for severe, gangrenous ischemia.

Keywords:
Ischemic colitiscolectomycolonoscopygastrointestinal bleedingproctosigmoiditis

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Last Updated: Jun 17, 2026

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
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Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Published on: May 18, 2018

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)
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Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)

Published on: January 19, 2010

Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

Area of Science:

  • Gastroenterology
  • Vascular Medicine

Background:

  • Ischemic colitis is the most frequent type of gastrointestinal ischemia.
  • It often results from nonocclusive vascular disease, though the precise mechanisms are not fully understood.

Purpose of the Study:

  • To summarize the presentation, diagnosis, and management of ischemic colitis.
  • To highlight the importance of disease severity in determining patient outcomes.

Main Methods:

  • Review of clinical presentation, diagnostic methods (colonoscopy), and treatment strategies.
  • Categorization of treatment based on disease severity (mucosal vs. transmural).

Main Results:

  • Common symptoms include abdominal discomfort and bloody diarrhea.
  • Diagnosis is typically confirmed via colonoscopy.
  • Treatment ranges from supportive medical management to surgical intervention based on ischemia severity.

Conclusions:

  • Prompt recognition and appropriate treatment are crucial for favorable outcomes in ischemic colitis.
  • The condition can lead to chronic issues like colitis or colonic strictures.
  • Patient outcomes are directly linked to disease severity and timely, effective management.