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Updated: Jun 17, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Treatment of bipolar disorder
Jeffrey Ventimiglia1, Amir H Kalali, Roger McIntyre
1Mr. Ventimiglia is an analyst in the Drug Safety and Medical Affairs Department, Quintiles, Inc., Falls Church, Virginia.
Abstract:
In this article, we investigate the range of treatments prescribed for bipolar disorder. Our analysis shows that, while a large portion of patients is treated by a single mechanism of action (44%), an equally sizable group of patients receives two or more drug classes (56%) to treat the disorder. From a therapeutic class perspective, 71 percent of patients with bipolar disorder receive an atypical antipsychotic, 53 percent receive a mood stabilizer, and 30 percent receive an antidepressant. While antipsychotics and mood stabilizers represent the vast majority of bipolar disorder monotherapy (90%), antidepressants are more commonly seen as part of a combination treatment.
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