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Related Experiment Video

Updated: Jun 17, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

Hemosiderin: a new marker for sentinel lymph node identification.

Luiz Gonzaga Porto Pinheiro1, Renato Santos de Oliveira Filho, Paulo Henrique Diógenes Vasques

  • 1Department of Surgery, Faculty of Medicine, UFC, Fortaleza, CE, Brazil. luizgporto@uol.com.br

Acta Cirurgica Brasileira
|December 17, 2009
PubMed
Summary

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Researchers explored hemosiderin, a blood derivative, as a novel marker for mammary sentinel lymph node identification in dogs. This study presents preliminary findings on hemosiderin

Area of Science:

  • Veterinary Medicine
  • Surgical Oncology
  • Biomedical Research

Background:

  • Sentinel lymph node biopsy is crucial for cancer staging.
  • Current methods using blue dyes have limitations and side effects.
  • Hemosiderin, a blood breakdown product, was theorized to be a potential lymphatic tracer.

Purpose of the Study:

  • To evaluate hemosiderin as a novel marker for mammary sentinel lymph node identification.
  • To present initial results from an experimental animal model.

Main Methods:

  • Six female dogs were used in the experimental model.
  • Technetium was injected into mammary glands.
  • Hemosiderin (hemolyzed blood) and patent blue dye were injected into lymphatic plexuses.
  • Lymphatic mapping and gamma probe were used to identify sentinel lymph nodes in the axillae.

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Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
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Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

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Last Updated: Jun 17, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

Main Results:

  • Seven brown sentinel lymph nodes were identified and radiomarked on the left axilla using hemosiderin.
  • Six blue sentinel lymph nodes were identified and radiomarked on the right axilla using patent blue dye.

Conclusions:

  • Preliminary results suggest hemosiderin is a viable marker for sentinel lymph node identification.
  • Hemosiderin may offer an alternative to current blue dyes, potentially mitigating patient side effects.