[Adenocarcinoma and intestinal duplication of the ileum. Report of one case]

Marcelo A Beltrán1, Carlos Barría, Mario A Contreras

  • 1Servicio de Cirugía, Hospital de La Serena, Chile. beltran_01@yahoo.com

Revista Medica De Chile
|December 17, 2009
PubMed

Insights

Gastrointestinal duplication in an adult female presented as a cystic tumor. This rare abnormality was found to be a mucinous adenocarcinoma with extensive peritoneal metastasis, leading to a fatal outcome.

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Developmental Biology

Background:

  • Gastrointestinal duplications are rare congenital anomalies, typically diagnosed in childhood.
  • Adult presentations are infrequent and often present with nonspecific symptoms.

Observation:

  • A 36-year-old female presented with abdominal pain.
  • Computed tomography revealed a cystic structure surrounded by small bowel loops and free peritoneal fluid.
  • Surgical exploration identified extensive peritoneal carcinomatosis and a large mesenteric cystic tumor.

Findings:

  • The mesenteric tumor exhibited features of intestinal wall architecture.
  • Histopathology confirmed a moderately differentiated mucinous adenocarcinoma infiltrating the cystic wall.
  • The tumor showed extensive infiltration of the peritoneum and omentum.

Implications:

  • This case highlights the rare occurrence of malignant transformation within a gastrointestinal duplication in an adult.
  • It underscores the importance of considering rare diagnoses in adult abdominal pathologies.
  • The advanced stage at presentation suggests a poor prognosis for such malignancies.

Related Concept Videos

Intestinal Obstruction I: Introduction01:29

Intestinal Obstruction I: Introduction

Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...
Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...