Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial and epithelial cell adhesion molecules.

S M Albelda1

  • 1Department of Medicine, University of Pennsylvania, Philadelphia.

American Journal of Respiratory Cell and Molecular Biology
|March 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Using macrophage activation to augment immunotherapy of established tumours.

British journal of cancer·2013
Same author

Identification of human-selective analogues of the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).

British journal of cancer·2013
Same author

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis.

Oncogene·2012
Same author

Neoadjuvant in situ gene-mediated cytotoxic immunotherapy improves postoperative outcomes in novel syngeneic esophageal carcinoma models.

Cancer gene therapy·2011
Same author

Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1/CD31): A Multifunctional Vascular Cell Adhesion Molecule.

Trends in cardiovascular medicine·2011
Same author

Eighth international mesothelioma interest group.

Oncogene·2007
Same journal

METRNL in bacterial pneumonia, what's new for a new cytokine.

American journal of respiratory cell and molecular biology·2026
Same journal

The Fat of the Matter: IL6-Driven Lipid Rewiring in COPD.

American journal of respiratory cell and molecular biology·2026
Same journal

Push, Pull, Protect: Piezo1 as the Force Gatekeeper of Immunity.

American journal of respiratory cell and molecular biology·2026
Same journal

Correction to: Protective Role of Apelin in a Mouse Model of Post-Intensive Care Syndrome.

American journal of respiratory cell and molecular biology·2026
Same journal

Correction to: Sex-Specific Perinatal Nicotine-Induced Asthma in Rat Offspring.

American journal of respiratory cell and molecular biology·2026
Same journal

NF-κB-Dependent Transcriptional Regulation of Piezo1 Mediates Bacterial Clearance on Infected Lung Stiffness.

American journal of respiratory cell and molecular biology·2026
See all related articles

This review explores lung cell adhesion molecules, including integrins and cadherins, crucial for lung structure, inflammation, and disease. These molecules mediate cell-substratum and cell-cell interactions, impacting lung health and disease progression.

Area of Science:

  • Pulmonary Cell Biology
  • Molecular Immunology
  • Biochemistry

Background:

  • Lung endothelial and epithelial cells express diverse cell adhesion molecules.
  • These molecules are critical for maintaining lung tissue structure and function.
  • Dysregulation of cell adhesion is implicated in lung pathologies.

Purpose of the Study:

  • To review specific cell adhesion molecules on lung endothelial and epithelial cells.
  • To discuss their roles in cell-substratum and cell-cell interactions.
  • To highlight their involvement in pulmonary inflammation, wound healing, and cancer metastasis.

Main Methods:

  • Literature review of cell adhesion molecules in the lung.
  • Categorization of molecules based on cellular location (abluminal, cell-cell borders, luminal).

Related Experiment Videos

  • Analysis of functional roles in normal physiology and disease processes.

    • Main Results:

    • Ablumninal molecules (integrins, proteoglycans, CD44) mediate cell-substratum adhesion.
    • Cell-border molecules (cadherins, integrins, PECAM-1) mediate cell-cell adhesion.
    • Inducible luminal molecules (ELAM-1, GMP140, ICAM-1, VCAM-1) facilitate immune cell and tumor cell adhesion during inflammation.

    Conclusions:

    • Cell adhesion molecules are vital for normal lung structure and function.
    • These molecules play key roles in inflammatory responses and wound healing.
    • Aberrant expression of adhesion molecules contributes to lung disease pathogenesis and metastasis.