[Acute prostatism associated with milnacipran therapy: a case report]

Area of Science:

• Pharmacology
• Urology
• Psychiatry

Background:

• Milnacipran is a serotonin and noradrenaline reuptake inhibitor used for major depressive disorder.
• It is generally considered safe and well-tolerated in clinical practice.

Observation:

• A 38-year-old male patient developed acute prostatism symptoms, including urinary hesitancy and incomplete emptying, within 24 hours of starting milnacipran.
• These symptoms resolved within 24 hours of drug discontinuation.

Findings:

• The patient had no other medical conditions or medications that could explain the symptoms.
• A direct association between milnacipran use and the onset of acute prostatism was suggested.

Implications:

• This case highlights a potential adverse effect of milnacipran, inducing acute prostatism.
• Physicians should be aware of this possibility and inform patients about potential urinary symptoms.
• The urinary side effects might be beneficial for patients with urinary incontinence.