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Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

Psychoneuroimmunology: Diabetes and Cancer

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

Mechanism of Angiogenesis

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
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Neurogenesis and Regeneration of Nervous Tissue

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Related Experiment Video

Updated: Jun 17, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

[VEGF and central nervous system diseases].

Lu-Yi Zhang¹, Yan-Ying Fan, Zhong Liu

¹Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310058, China.

Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences

|December 17, 2009

Summary

Vascular endothelial growth factor (VEGF) promotes nerve cell survival and growth. Research links VEGF to central nervous system diseases, suggesting potential new therapeutic targets.

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Last Updated: Jun 17, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

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In Vitro Model of Coronary Angiogenesis

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Published on: March 10, 2020

Area of Science:

Molecular biology
Neuroscience
Angiogenesis research

Context:

Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel formation.
VEGF plays crucial roles in neurotrophy, neuroprotection, anti-apoptosis, and cell proliferation.
Emerging evidence implicates VEGF in the pathology of central nervous system (CNS) diseases.

Purpose:

To explore the multifaceted roles of VEGF in the CNS.
To investigate the association between VEGF and neurodegenerative diseases.
To identify potential therapeutic strategies targeting VEGF for CNS disorders.

Summary:

VEGF, a hypoxia-induced angiogenic factor, exhibits neuroprotective and pro-survival effects.
VEGF is implicated in central nervous system disorders including cerebral ischemia, Alzheimer's disease, and Parkinson's disease.
Further research into VEGF's CNS functions and related therapeutics is warranted.

Impact:

Understanding VEGF's role can illuminate novel treatment pathways for debilitating neurological conditions.
This research may pave the way for developing innovative drugs targeting VEGF for CNS diseases.
Highlights the therapeutic potential of modulating VEGF in neurodegenerative and ischemic conditions.