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Proton-Sensitive Receptors/Channels: Therapeutic Target for Ischemic Stroke, Focusing on Their Roles and Mechanisms
Yao Cheng1,2, Yu-Jie Zhai1,2, Shao-Shuai Wang3
1Department of Pharmacology, School of Basic Medical Science, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Current Neuropharmacology
|July 22, 2025
Summary
Proton-sensing receptors are crucial in ischemic stroke. Targeting these channels offers new therapeutic strategies for brain injury and stroke intervention.
Area of Science:
- Neuroscience
- Biochemistry
- Pathophysiology
Background:
- Ischemic stroke involves complex pathophysiological mechanisms and unclear therapeutic targets.
- Brain acid-base balance is vital; disruption leads to acidosis during cerebral ischemia.
- Proton-sensing receptors/channels play key roles in response to pH changes.
Purpose of the Study:
- To review the roles of proton-sensing receptors/channels in ischemic stroke.
- To highlight novel insights into their mechanisms and functions in brain injury.
- To emphasize their significance as therapeutic targets for stroke intervention.
Main Methods:
- Literature review of recent studies on proton-sensing receptors/channels in ischemic stroke.
- Analysis of their recognition, activation, and subcellular distribution.
- Examination of their involvement in neuroprotection, neurorestoration, and neuroinflammation.
Main Results:
- Proton-sensing receptors, including acid-sensing ion channels, are implicated in ischemic stroke pathophysiology.
- These channels exhibit distinct mechanisms in response to acidosis.
- Novel functions and distributions of these receptors offer deeper insights into brain injury.
Conclusions:
- Proton-sensing receptors/channels are significantly involved in ischemic stroke.
- Targeting these pathways presents promising therapeutic avenues for stroke intervention.
- Further research into these targets can advance novel treatment strategies.
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