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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: Jun 17, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Update on melanoma: the present position.

Daryl Godden1, Peter A Brennan, James Milne

  • 1Department of Maxillofacial Surgery, Gloucestershire Royal Hospital, Great Western Road, Gloucester GL1 3NN, United Kingdom. daryl.godden@glos.nhs.uk

The British Journal of Oral & Maxillofacial Surgery
|December 18, 2009
PubMed
Summary

Melanoma prevention is key to controlling its rising incidence, especially in fair-skinned individuals. Effective management involves organized skin cancer services, surgical progress, and neoadjuvant therapies.

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Last Updated: Jun 17, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
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Published on: May 18, 2018

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Area of Science:

  • Dermatology
  • Oncology
  • Surgical Oncology

Background:

  • Cutaneous melanoma incidence is rising, particularly in fair-skinned populations.
  • Ultraviolet radiation exposure from sunbathing, sunbeds, and travel is a primary risk factor.
  • Melanoma commonly affects the head and neck region, increasing surgical involvement.

Purpose of the Study:

  • To review the current management philosophy for cutaneous melanoma.
  • To highlight the importance of prevention in controlling the melanoma epidemic.
  • To discuss the role of surgical and neoadjuvant treatments in melanoma care.

Main Methods:

  • Literature review of current melanoma management strategies.
  • Analysis of epidemiological trends and risk factors for cutaneous melanoma.
  • Examination of advancements in surgical techniques and neoadjuvant therapies.

Main Results:

  • Prevention strategies are crucial for controlling melanoma incidence.
  • Organized skin cancer services improve patient outcomes.
  • Surgical advances and neoadjuvant treatments are vital components of melanoma management.
  • Head and neck surgeons play an increasing role in managing melanoma patients.

Conclusions:

  • A multi-faceted approach including prevention, organized services, and advanced treatments is essential for melanoma control.
  • Early detection and comprehensive management, especially in the head and neck, are critical.
  • Continued research into neoadjuvant therapies and surgical techniques is warranted.