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Capsaicin-induced central sensitization evokes segmental increases in trigger point sensitivity in humans
John Z Srbely1, James P Dickey, Leah R Bent
1Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada. jsrbely@uoguelph.ca
The Journal of Pain
|December 18, 2009
Summary
Inducing central sensitization increases trigger point pain sensitivity in related muscles. This finding is crucial for understanding and managing myofascial pain syndrome.
Area of Science:
- Neuroscience
- Pain Research
- Musculoskeletal Medicine
Background:
- Myofascial pain syndrome is a common condition characterized by myofascial trigger points.
- Understanding the role of central sensitization in trigger point pathophysiology is key for effective pain management.
Purpose of the Study:
- To investigate if inducing central sensitization leads to increased trigger point pressure sensitivity.
- To determine the segmental influence on trigger point sensitivity.
Main Methods:
- Central sensitization was induced in the C(5) segment using topical capsaicin cream.
- Mechanical cutaneous sensitivity (brush allodynia) validated central sensitization.
- Pain pressure threshold (PPT) was measured at infraspinatus and gluteus medius trigger points.
Main Results:
- Subjects with induced central sensitization showed significantly increased brush allodynia.
- A significant decrease in PPT was observed at segmentally related trigger points (infraspinatus) compared to controls.
- These findings indicate that central sensitization directly influences trigger point sensitivity.
Conclusions:
- Increased central sensitization evokes heightened trigger point pressure sensitivity in segmentally related muscles.
- This research contributes to understanding the mechanisms underlying myofascial pain.
- Further elucidation of central sensitization's role is vital for optimizing myofascial pain syndrome management.
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