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Updated: Jun 17, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Bronchus-associated lymphoid tissue lymphomas.

Konstantinos Arnaoutakis¹, Thein H Oo

¹St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA.

Southern Medical Journal

|December 18, 2009

Summary

Bronchus-associated Lymphoid Tissue (BALT) lymphomas are rare lung cancers. These lymphomas have an excellent prognosis and survival outcomes with various treatment options.

Area of Science:

Oncology
Immunology
Pathology

Background:

Bronchus-associated Lymphoid Tissue (BALT) lymphomas are a rare extranodal marginal zone lymphoma subtype.
They represent 1% of all lymphomas and over two-thirds of primary non-Hodgkin lymphoma (NHL) of the lung.
BALT lymphomas originate from the bronchus-associated lymphoid tissue.

Observation:

This report details five cases of BALT lymphoma.
The study discusses the pathogenesis, diagnosis, prognosis, and treatment strategies for BALT lymphomas.
Patients in the cohort were managed using surgery, watchful waiting, chemotherapy, immunotherapy, and chemoimmunotherapy.

Findings:

BALT lymphomas are linked to chronic inflammation and can be asymptomatic.
These lymphomas exhibit an indolent clinical course.

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Last Updated: Jun 17, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

The study reports excellent survival outcomes, with a projected 5-year survival rate of 100%.

Implications:

BALT lymphomas demonstrate a favorable prognosis across diverse treatment modalities.
Effective management strategies include surgery, watchful waiting, radiotherapy, chemotherapy, immunotherapy, and chemoimmunotherapy.
Understanding the indolent nature and excellent survival outcomes is crucial for patient management and treatment planning.