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Related Concept Videos

Antipsychotic Drugs: Typical and Atypical Agents01:21

Antipsychotic Drugs: Typical and Atypical Agents

Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
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Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

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Drug Therapy01:28

Drug Therapy

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Antianxiety Medications
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Psychosis and Antipsychotic Drugs: Overview

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Related Experiment Video

Updated: Jun 17, 2026

Self-Administration of Drugs in Mouse Models of Feeding and Obesity
03:37

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

Priapism and risperidone.

Sharad Koirala1, Praveen Penagaluri, Carolyn Smith

  • 1Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA.

Southern Medical Journal
|December 18, 2009
PubMed
Summary
This summary is machine-generated.

Risperidone, an antipsychotic, can cause priapism, a prolonged erection. This risk is heightened in patients with sickle cell disease, or those using cocaine or alcohol.

Related Experiment Videos

Last Updated: Jun 17, 2026

Self-Administration of Drugs in Mouse Models of Feeding and Obesity
03:37

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

Area of Science:

  • Pharmacology
  • Urology

Background:

  • Risperidone is an antipsychotic medication used to treat mental health conditions.
  • Priapism is a medical emergency characterized by prolonged penile erection.

Observation:

  • Two cases of priapism are presented in patients using risperidone.
  • One patient was using cocaine and alcohol concurrently with injectable risperidone.
  • The second patient had a history of sickle cell disease and was on oral risperidone.

Findings:

  • Risperidone is an established cause of priapism.
  • Concurrent use of cocaine and alcohol, and pre-existing sickle cell disease significantly increase the risk of risperidone-induced priapism.
  • Outcomes varied, with one patient requiring penectomy and the other recovering erectile function.

Implications:

  • Physicians must consider priapism risk factors, including substance abuse and sickle cell disease, when prescribing risperidone.
  • Awareness of these combined risks is crucial for preventing severe outcomes associated with priapism.
  • This highlights the importance of a thorough patient history and risk assessment in psychopharmacology.