Related Experiment Video
Updated: Jan 31, 2026
07:24
Hyperspectral Imaging as a Tool to Study Optical Anisotropy in Lanthanide-Based Molecular Single Crystals
Published on: April 14, 2020
18.6K
Lanthanide complexes for magnetic resonance and optical molecular imaging
S Laurent1, L Vander Elst, R N Muller
1Department of General Organic and Biomedical Chemistry Laboratory of NMR and Molecular Imaging, University of Mons, Mons, Belgium.
Summary
Lanthanide complexes offer dual-mode biomedical imaging capabilities for both magnetic resonance imaging (MRI) and optical imaging. These paramagnetic contrast agents (CA) provide enhanced information through simultaneous visualization, overcoming limitations of individual techniques.
Area of Science:
- Biomedical imaging
- Coordination chemistry
- Materials science
Background:
- Lanthanide complexes are increasingly utilized as contrast agents (CA) in biomedical imaging.
- Magnetic resonance imaging (MRI) and optical imaging have complementary strengths and weaknesses.
- Bimodal agents offer simultaneous visualization, enhancing diagnostic information.
Purpose of the Study:
- To review the properties of lanthanide ions and their complexes for bimodal imaging.
- To highlight applications of lanthanide-based contrast agents.
- To compare the performance of novel Gd complexes with existing clinical agents.
Main Methods:
- Review of lanthanide coordination chemistry.
- Analysis of luminescence properties (quantum yield, lifetime).
- Evaluation of relaxometric data for Gadolinium (Gd) complexes.
Main Results:
- Lanthanide complexes exhibit high quantum yield and long luminescence lifetimes.
- Gd complexes demonstrate relaxometric properties comparable or superior to commercial MRI contrast agents.
- Bimodal agents integrate MRI and optical imaging capabilities.
Conclusions:
- Lanthanide complexes represent a promising platform for advanced bimodal biomedical imaging.
- These agents can overcome the limitations of単一-mode imaging techniques.
- Further development of lanthanide complexes can lead to improved diagnostic tools.
Related Concept Videos
01:27Imaging Studies IV: Magnetic Resonance Imaging
276
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
276
01:24Magnetic Resonance Imaging
9.3K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
9.3K
01:05Atomic Nuclei: Magnetic Resonance
1.2K
The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
1.2K
01:07Nuclear Magnetic Resonance (NMR): Overview
6.9K
Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
6.9K
02:52Resonance
65.2K
The Lewis structure of a nitrite anion (NO2−) may actually be drawn in two different ways, distinguished by the locations of the N-O and N=O bonds.
65.2K
03:02Colors and Magnetism
14.1K
Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
14.1K