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Updated: Jun 17, 2026

Isolation of Murine Lymph Node Stromal Cells
Published on: August 19, 2014
Mechanisms maintaining peripheral tolerance
1Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA. muell002@umn.edu
Abstract:
The presentation of self-peptide-MHC complexes in the periphery to potentially autoreactive T cells that have escaped negative selection in the thymus poses an important problem to the immune system. In this review, I discuss data that reveal barriers preventing peripheral T cell recognition of self-peptide-MHC complexes, as well as the physiological mechanisms that ensure the elimination or functional inactivation (anergy) of T cells that do come to recognize self-peptide-MHC and threaten the health of the individual.
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